Julius-Maximilians-Universität Würzburg

Bettina Böttcher

Anschrift:

Leistungsprofil:

• Strukturbiologie
• Elektronenmikroskopie

• Struktur und Funktion von Mechanosensitiven Kanälen

• Elektronen-Kryo Mikroskop
• Bedampfungsanlage
• Vitrobot
• Bildverarbeitung

Publikationen:

• Bottcher B, Prazak V, Rasmussen A, Black SS, Rasmussen T (2015) The Structure of YnaI Implies Structural and Mechanistic Conservation in the MscS Family of Mechanosensitive Channels. Structure 23: 1705-14
• Sundaramoorthy R, Hughes AL, Singh V, Wiechens N, Ryan DP, El-Mkami H, Petoukhov M, Svergun DI, Treutlein B, Quack S, Fischer M, Michaelis J, Bottcher B, Norman DG, Owen-Hughes T (2017) Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes. Elife 6
• Hipp K, Galani K, Batisse C, Prinz S, Boettcher B (2012) Modular architecture of eukaryotic RNase P and RNase MRP revealed by electron microscopy. Nucleic Acids Research 40: 3275-3288
• Gerlach B, Kleinschmidt J, Bottcher B (2011) Conformational Changes in Adeno-Associated Virus Type 1 Induced by Genome Packaging. Journal of Molecular Biology 409: 427-438
• Fernandez-Tornero C, Bottcher B, Rashid U, Steuerwald U, Florchinger B, Devos D, Lindner D, Muller C (2010) Conformational flexibility of RNA polymerase III during transcriptional elongation. Embo Journal 29: 3762-3772
• Ulbrich C, Diepholz M, Bassler J, Kressler D, Pertschy B, Galani K, Bottcher B, Hurt E (2009) Mechanochemical Removal of Ribosome Biogenesis Factors from Nascent 60S Ribosomal Subunits. Cell 138: 911-922
• Seitz S, Urban S, Antoni C, Bottcher B (2007) Cryo-electron microscopy of hepatitis B virions reveals variability in envelope capsid interactions. Embo Journal 26: 4160-4167
• Kuhner S, van Noort V, Betts M, Leo-Macias A, Batisse C, Rode M, Yamada T, Maier T, Bader S, Beltran-Alvarez P, Castano-Diez D, Chen W, Devos D, Guell M, Norambuena T, Racke I, Rybin V, Schmidt A, Yus E, Aebersold R et al. (2009) Proteome Organization in a Genome-Reduced Bacterium. Science 326: 1235-1240
• Aloy P, Bottcher B, Ceulemans H, Leutwein C, Mellwig C, Fischer S, Gavin A, Bork P, Superti-Furga G, Serrano L, Russell R (2004) Structure-based assembly of protein complexes in yeast. Science 303: 2026-2029

Kooperationsangebot für die Wirtschaft / Praxis:

• Entwicklung von Methoden für die Kryo-Elektronenmikroskopie
• Messung von Proben für die Elektronenkryomikroskopie