Universität Regensburg

Barbara Schmidt

Anschrift:

Leistungsprofil:

• Rolle der Typ I-Interferone in der HIV-1 Immunpathogenese
• Untersuchung des Eintritts von HIV-1 in die Zielzellen
• Entwicklung neuer immuntherapeutischer HSV-1 Vektoren

• Durchflußzytometrie
• quantitative PCR
• Sequenzierung
• Bestimmung proinflammatorischer Zytokine
• Herstellung rekombinanter Viren

Publikationen:

• Tennert, K., Schneider, L., Bischof, G., Korn, K., Harrer, E., Harrer, T., & Schmidt, B. for the German Competence Network HIV/AIDS. Elevated CD40 ligand silences alpha interferon production in an HIV-related immune reconstitution inflammatory syndrome. AIDS (in press).
• Donhauser, N., Pritschet, K., Helm, M., Harrer, T., Schuster, P., Ries, M., Bischof, G., Vollmer, J., Smola, S. & Schmidt, B. for the German Competence Network HIV/AIDS (2012). Chronic immune activation in HIV-1 infection contributes to reduced interferon alpha production via enhanced CD40:CD40 ligand Interaction. PLoS ONE 7(3):e33925.
• Pritschet, K., Donhauser, N., Schuster, P., Ries, M., Haupt, S., Kittan N. A., Korn, K., Pöhlmann, S., Holland, G., Bannert, N., Bogner, E. & Schmidt, B. (2012). CD4- and dynamin-dependent endocytosis of HIV-1 into plasmacytoid dendritic cells. Virology 423: 152-164.
• Ries, M., Pritschet, K. & Schmidt, B. (2012). Blocking type I interferon production - a new therapeutic option to reduce the HIV-1 induced immune activation. Clin. Dev. Immunol., 534929.
• Kasang, C., Ulmer, A., Donhauser, N., Schmidt, B., Stich, A., Klinker, H., Kalluvya, S., Koutsilieri, E., Rethwilm, A., & Scheller, C. (2012). HIV patients treated with low-dose prednisolone exhibit lower immune activation than untreated patients. BMC. Infect. Dis. 12, 14.
• Schuster, P., Boscheinen, J. B., Tennert, K. & Schmidt, B. The role of plasmacytoid dendritic cells (PDC) in innate and adaptive immune responses against alpha herpes virus infections (2011). Advances in Virology, doi:10.1155/2011/679271.
• Jantsch, J., Schmidt, B., Bardutzky, J., Bogdan, C., Eckhardt, K. U. & Raff, U. (2011). Lethal varicella-zoster virus reactivation without skin lesions following renal transplantation. Nephrol. Dial. Transplant. 26: 365-368.
• Donhauser, N., Helm, M., Pritschet, K., Schuster, P., Ries, M., Korn, K., Vollmer, J. & Schmidt, B. (2010). Differential effects of P-class versus other CpG oligodeoxynucleotide classes on the impaired innate immunity of plasmacytoid dendritic cells in HIV-1 infection. AIDS Res. Hum. Retrovir. 26: 161-171.
• Schuster, P., Donhauser, N., Pritschet, K., Ries, M., Haupt, S., Kittan, N.A., Korn, K., & Schmidt, B. (2010). Coordinated regulation of plasmacytoid dendritic cell surface receptors upon stimulation with herpes simplex virus type 1. Immunology Schuster, P., Donhauser, N., Pritschet, K., Ries, M., Haupt, S., Kittan, N.A., Korn, K., & Schmidt, B. (2010). Coordinated regulation of plasmacytoid dendritic cell surface receptors upon stimulation with herpes simplex virus type 1. Immunology 129: 234-247.

Kooperationsangebot für die Wirtschaft / Praxis:

• Untersuchung von Substanzen, welche den Eintritt von HIV-1 in die Zielzellen hemmen
• Medikamentöse Intervention bei Immunstimulation
• neue Ansätze zur Immuntherapie bei Malignem Melanom

Bestehende Kooperationen: