Universität Regensburg

Samuel Tobias Sossalla

Anschrift:

Leistungsprofil:

• Zelluläre Elektrophysiologie
• Herzinsuffizienz
• Mechanismen und Therapien der Arrhythmie
• Interventionelle Kardiologie
• klinische Studien

• Bedeutung des neuronalen Natriumkanal Nav1.8 für die Arrhythmogenese
• Mechanismen der Tachykardiomyopathie iPS-zellgestütztes Projekt Sowie mittels humaner kardiomyozyten
• Mechanismen der SGLT1 Inhibition mittels Empagliflozin im Myokard
• Charakterisierung der Arrhythmie-induzierten Kardiomyopathie: Entwicklung eines diagnostischen Models für die frühe Diagnose der AIC (TACHY-HF Studie)

• Humanzellisolation aus explantierten Herzen
• Murine Kardiomyozytenisolation
• Epifluoreszenzmessungen und Zellverkürzungen
• Patch-Clamp-Technik
• Konfokale Lasermikroskopie

Publikationen:

• 1. Schillinger W, Teucher N, Christians C, Kohlhaas M, Sossalla S, Van Nguyen P, Schmidt AG, Schunck O, Nebendahl K, Maier LS, Zeitz O, Hasenfuss G. High intracellular Na+ preserves myocardial function at low heart rates in failing hearts. Eur J Heart Fail. 2006; 8:673-680. 2. Schillinger W, Christians C, Sossalla S, Teucher N, Van Nguyen P, Kögler H, Zeitz O, Hasenfuss G. Alpha1-Adrenergic Stress Induces Downregulation of Na+/Ca+ Exchanger In Myocardial Preparations From Rabbits At Physiological Preload. Eur J Heart Fail. 2007; 9:329-335. 3. Schillinger W, Teucher N, Sossalla S , Kettlewell S, Raddatz D, Werner C, Elgner A, Tenderich G, Pieske B, Schöndube FA, Kögler H, Kockskämper J, Maier LS, Schwörer H, Smith GL, Hasenfuss G. Negative Inotropy of the Gastric Proton Pump Inhibitor Pantoprazole in Myocardium from Humans and Rabbits. Evaluation of Mechanisms. Circulation. 2007; 116:57-66. 4. Sossalla S, Wagner S, Rasenack ECL, Ruff H, Weber SL, Tirilomis T, Tenderich G, Schondube FA, Hasenfuss G, Belardinelli L, Maier LS. Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts – Role of late sodium current and intracellular ion accumulation. J Mol Cell Cardiol. 2008; 45:32-43. Kommentar in: J Mol Cell Cardiol. 2008; 45:28-31. 5. Sohns C, Heuser M, Sossalla S, Wolff H, Obenauer S. Current role and future potential of computed tomographic colonography for colorectal polyp detection and colon cancer screening-incidental findings. Clin Imaging. 2008; 32:280-286. 6. Sohns C, Amarteifio E, Sossalla S, Heuser M, Obenauer S. 64-Multidetector-row spiral CT in pulmonary embolism with emphasis on incidental findings. Clin Imaging. 2008; 32:335-341. 7. Schmitto JD, Doerge H, Post H, Coulibaly M, Sellin C, Popov AF, Sossalla S, Schoendube FA. Progressive right ventricular failure is not explained by myocardial ischemia in a pig model of right ventri- cular pressure overload. Eur J Cardiothorac Surg. 2009; 5:9-34. 8. Schillinger W, Hörnes N, Teucher N, Sehrt D, Jung K, Sossalla S, Kleta S, Hünlich M, Geiling B, Unsöld B, Ramadori G, Hilgers R, Schwörer H, Hasenfuss G. Recent in vitro findings of negative inotropy of pantoprazole did not translate into clinically relevant effects on left ventricular function in healthy volunteers. A randomized cross-over trial. Clin Res Cardiol. 2009; 98:391-399. 9. Wagner S, Hacker E, Dybkova N, Sossalla S, Fabritz L, Kirchhoff P, Bers DM, Maier LS. Ca/calmodulin kinase II differentially modulates transient outward potassium current in heart failure. Circ Arrhythmia Electrophysiol. 2009; 2:285-294. 10. Schmitto JD, Popov AF, Sossalla S, Coskun KO, Mokashi SA, Wintner A, Schoendube FA. Daptomycin for treatment of methicillin-resistant Staphylococcus epidermidis saphenectomy wound infection after coronary artery bypass graft operation (CABG). J Cardiothorac Surg. 2009; 11:40-47. 11. Schmitto JD, Kolat P, Ortmann P, Popov AF, Coskun KO, Friedrich M, Sossalla S, Toischer K, Mokashi SA, Tirilomis T, Baryalei MM, Schoendube FA. Early results of coronary artery bypass grafting with coronary endarterectomy for severe coronary artery disease. J Cardiothorac Surg. 2009; 4:52. 12. Schmitto JD, Coskun KO, Coskun ST, Ortmann P, Vorkamp T, Heidrich F, Sossalla S, Popov AF, Tirilomis T, Hinz J, Heuer J, Quintel M, Chen FY, Schöndube FA. Hemodynamic Changes in a Model of Chronic Heart Failure Induced by Multiple Sequential Coronary Microembolization in Sheep. Artif Organs. 2009; 33:947-52. 13. Villari B, Sossalla S, Ciampi Q, Petruziello B, Turina J, Turina M, Hess OM. Persistent diastolic dysfunction late after aortic valve replacement in severe aortic regurgitation. Circulation. 2009; 120:2386-92. 14. Neef S*, Dybkova N*, Sossalla S*, Ort K, Fluschnik N, Neumann K, Seipelt R, Schöndube FA, Hasenfuss G, Maier LS. CaMKII-Dependent Diastolic SR Ca2+ Leak and Elevated Diastolic Ca2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation. Circ Res. 2010; 106:1134-44. *=geteilte Erstautorenschaft 15. Sossalla S, Kallmeyer B, Wagner S, Mazur M, Maurer U, Toischer K, Schmitto JD, Seipelt R, Schöndube FA, Hasenfuss G, Belardinelli L, Maier LS. Altered Na+ currents in atrial fibrillation – Effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J Am Coll Cardiol. 2010; 55:2330-42. Kommentar in: J Am Coll Cardiol. 2010; 55:2343-2345. 16. Sohns C, Sossalla S, Schmitto JD, Jacobshagen C, Raab BW, Obenauer S, Maier LS. Visualization of transcoronary ablation of septal hypertrophy in patients with hypertrophic obstructive cardiomyopathy: a comparison between cardiac MRI, invasive measurements and echocardiography. Clin Res Cardiol. 2010; 99:359-68. 17. Sohns C, Mangelsdorf J, Sossalla S, Konietschke F, Obenauer S. Measurement of response of pulmonal tomors in 64-slice MDCT. Acta Radiol. 2010; 51:512-21. 18. Sohns C, Sossalla S, Vollmann D, Luethje L, Seegers J, Schmitto JD, Zabel M, Obenauer S. Extra cardiac findings by 64-multidetector computed tomography in patients with symptomatic atrial fibrillation prior to pulmonal vein isolation. Int J Cardiovasc Imaging. 2011; 27:127-34. 19. Toischer K; Rokita AG, Unsöld, Wuqiang Z, Sossalla S, Reuter SP, Becker A, Teucher N, Seidler T, Grebe C, Preuß L, Gupta SN, Schmidt K, Lehnart SE, Krüger M, Linke WA, Kararigas G, Regitz-Zagrosek V, Backs J, Schäfer K, Field LJ, Maier LS, Hasenfuss G: Differential cardiac remodeling in preload versus afterload. Circulation. 2010; 122:993-1003. Awarded as paper of the year Basic Science in Circulation 20. Sohns C, Angic B, Sossalla S, Konietschke F, Obenauer S. Computer-assisted Diagnosis in Full-field Digital Mammography-Results in Dependence of Readers Experiences. Breast J. 2010; 16:490-497. 21. Sossalla S, Fluschnik N, Ort K, Schotola H, Neef S, Schulte T, Renner A, Gummert J, Hasenfuss G, Maier LS. Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II (CaMKII) improves contractility in human failing myocardium. Circ Res. 2010. 107:1150-1161. Kommentar in: Circ Res. 2010; 107:1044-1046. 22. Schmitto JD, Popov AF, Coskun KO, Friedrich M, Sossalla S, Didilis V, Schoendube FA, Mirzaie M. Morphological investigations of type a aortic dissection. Ann Thorac Cardiovasc Surg. 2010; 16:331-334. 23. Heidrich F,* Sossalla S,* Schotola H, Vorkamp T, Ortmann P, Popov AF, Coskun KO, Rajab TK, Friedrich M, Sohns C, Hinz J, Bauer M, Quintel M, Schöndube FA, Schmitto JD. The Role of Phospho-AMPK and VEGF in a Model of Chronic Heart Failure. Artif Organs. 2010; 34:969-979. *=geteilte Erstautorenschaft 24. Schillinger W, Hünlich M, Sossalla S, Hermann HP, Hasenfuss G. Intracoronary Pyruvate In Cardiogenic Shock As An Adjunctive Therapy To Catecholamines And Intra-Aortic Balloon Pump Shows Beneficial Effects On Hemodynamics. Clin Res Cardiol. 2011; 100:433-438. 25. Sossalla S, Maurer U, Schotola H, Hartmann N, Didié M, Zimmermann WH, Jacobshagen C, Wagner S, Maier LS. Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδC can be reversed by inhibition of late Na+ current. Basic Res Cardiol. 2011; 106:263-272. 26. Sossalla S, Schotola H, Schmitto JD, Toischer K, Sohns C, Schwörer H, Hasenfuss G, Maier LS, Schillinger W. Effects of different proton pump inhibitors on cardiac contractility in isolated human failing myocardium. J Cardiovasc Surg. 2011; 52:437-447. 27. Mirzaie M, Fatehpur S, Friedrich M, Sossalla S, Sohns C, Schoendube FA, Schmitto JD. Complex reconstruction of supraaortic branches. Ann Thorac Cardiovasc Surg. 2011; 17:347-351. 28. Schotola H, Sossalla S, Taufiek KR, Toischer K, Quintel M, Bauer M, Schmitto JD. Influence of Mild Metabolic Acidosis on Cardiac Contractility and Isoprenaline Response in Isolated Ovine Myocardium. Artif Organs. 2011; 35:1065-1074. 29. Unsöld B, Schotola H, Jacobshagen C, Seidler T, Sossalla S, Emons J, Klede S, Knöll R, Guan K, El-Armouche A, Linke WA, Kögler H, Hasenfuss G. Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP). Eur J Heart Fail. 2012; 14:430-437. 30. Schotola H, Toischer K, Popov AF, Renner A, Schmitto JD, Gummert J, Quintel M, Bauer M, Maier LS, Sossalla S. Mild metabolic acidosis impairs the beta-adrenergic response in isolated human failing myocardium. Crit Care. 2012; 16:R153. Kommentar in: Crit Care. 2012; 16:160. 31. Luo M, Guan X, Luczak E, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla S, Swaminathan PD, Weiss R, Yang B, Rokita A, Maier LS, Efimov IR, Hund T, Anderson ME. Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest. 2013; 123:1262-1274. 32. Sohns C, Sohns JM, Bergau L, Sossalla S, Vollmann D, Lüthje L, Staab W, Dorenkamp M, Harrison JL, O'Neill MD, Lotz J, Zabel M. Pulmonary vein anatomy predicts freedom from atrial fibrillation using remote magnetic navigation for circumferential pulmonary vein ablation. Europace. 2013; 15:1136-42. 33. Toischer K, Hartmann N, Wagner S, Fischer TH, Herting J, Danner BC, Sag CM, Hund TJ, Mohler PJ, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S. Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease. J Mol Cell Cardiol. 2013; 61:111-22. 34. Fischer TH, Herting J, Tirilomis T, Renner A, Neef S, Toischer K, Ellenberger D, Förster A, Schmitto JD, Gummert J, Schöndube FA, Hasenfuss G, Maier LS, Sossalla S. CaMKII and PKA differentially regulate SR Ca2+-leak in human cardiac pathology. Circulation. 2013; 128:970-981. Kommentar in: Circulation. 2013; 128:941-943: 35. Vollmann D, Woronowicz S, Kmiec L, Jung K, Zenker D, Seegers J, Sossalla S, Dorenkamp M, Sohns C, Lüthje L, Hasenfuss G, Zabel M. Passive-fixation lead failure rates and long-term patient mortality in subjects implanted with Sprint Fidelis electrodes. Europace. 2013; 16:258-64. 36. Sohns C, von Gruben V, Sossalla S, Bergau L, Seegers J, Lüthje L, Vollmann D, Zabel M. Antiarrhythmic drug therapy for maintaining sinus rhythm early after pulmonary vein ablation in patients with symptomatic atrial fibrillation. Cardiovasc Ther. 2013; 32:7-12. 37. Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. J Am Coll Cardiol. 2013; 62:1596-606. 38. Schotola H, Bräuer A, Meyer K, Hinz J, Schöndube FA, Bauer M, Mohitec PN, Danner BC, Sossalla S, Popov AF. Perioperative outcomes of cardiac surgery patients with ongoing ticagrelor therapy: boon and bane of a new drug. Eur J Cardiothorac Surg. 2014; 46:198-205. 39. Sossalla S, Wallisch N, Toischer K, Sohns C, Vollmann D, Seegers J, Lüthje L, Maier LS, Zabel M. Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model. Cardiovasc Ther. 2014; 32:170-177. 40. Vollmann D, Lüthje L, Seegers J, Sohns C, Sossalla S, Sohns J, Röver C, Hasenfuß G, Zabel M. Remote magnetic navigation for circumferential pulmonary vein ablation: single-catheter technique or additional use of a circular mapping catheter? J Interv Card Electrophysiol. 2014; 41:65-73. 41. Lindner D, Zietsch C, Tank J, Sossalla S, Fluschnik N, Hinrichs S, Maier L, Poller W, Blankenberg S, Schultheiss HP, Tschöpe C, Westermann D. Cardiac fibroblasts support cardiac inflammation in heart failure. Basic Res Cardiol; 2014. 109:428. 42. Fischer TH, Eiringhaus J, Dybkova N, Förster A, Herting J, Kleinwächter A, Ljubojevic S, Schmitto JD, Streckfuß-Bömeke K, Renner A, Gummert J, Hasenfuss G, Maier LS, Sossalla S. CaMKII equally induces SR Ca2+ leak in human ischemic and dilated cardiomyopathy. Eur J Heart Fail. 2014; 16:1292-1300. Kommentar in: Eur J Heart Fail. 2014; 16:1268–1269. 43. Sag CM, Mallwitz A, Wagner S, Hartmann N, Schotola H, Fischer TH, Ungeheuer N, Herting J, Shah AM, Maier LS, Sossalla S* Unsöld B*. Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner. J Mol Cell Cardiol. 2014; 76:94-105. *=geteilte Letztautorenschaft 44. Unsöld B, Teucher N, Didié1 M, Sossalla S, Jacobshagen C, Seidler T, Schillinger W, Hasenfuss G. Negative hemodynamic effects of pantoprazole at high infusion rates in mice. Cardiovasc Ther. 2014; 33:20-26. 45. Bergau L, Sohns C, Sossalla S, Muñoz-Exposito P, Luethje L, Zabel M. Submuscular implantation of insertable cardiac monitors improves the reliability of detection of atrial fibrillation. J Interv Card Electrophysiol. 2015; 42:143-149. 46. Xu X, Tan X, Tampe B, Nyamsuren G, Liu X, Maier LS, Sossalla S, Kalluri R, Zeisberg M, Hasenfuss G, Zeisberg EM. Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis. Cardiovasc Res. 2015; 105:279-291. 47. Fischer T, Herting J, Mason FE, Hartmann N, Watanabe S, Nikolaev VO, Sprenger JU, Fan P, Yiao L, Popov AF, Danner BC, Schöndube F, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S. Late INa increases diastolic SR Ca2+ leak in atrial myocardium by activating PKA and CaMKII. Cardiovasc Res. 2015; 107:184-96. 48. Mirtschink P, Krishnan J, Grimm F, Sarre A, Hörl M, Kayikci M, Fankhauser N, Christinat Y, Cortijo C, Feehan O, Vukolic A, Sossalla S, Stehr SN, Ule J, Zamboni N, Pedrazzini T, Krek W. HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. Nature. 2015; 522:444-9. 49. Seegers J, Expósito PM, Lüthje L, Fischer T, Lueken M, Wenk H, Sossalla ST, Hasenfuss G, Zabel M. Longevity of implantable cardioverter-defibrillators in a single-center population. J Interv Card Electrophysiol. 2015; 44:179-86. 50. Fischer TH, Herting J, Eiringhaus J, Pabel S, Hartmann NH, Ellenberger D, Friedrich M, Renner A, Gummert J, Maier LS, Zabel M, Hasenfuss G, Sossalla S. Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure. Europace. 2016; 18:1440-8. 51. Seegers J, Conen D, Jung K, Bergau L, Dorenkamp M, Lüthje L, Sohns C, Sossalla ST, Fischer TH, Hasenfuss G, Friede T, Zabel M. Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators. Europace. 2016; 18:1194-202. 52. Fischer TH, Kleinwächter A, Herting J, Eiringhaus J, Hartmann N, Renner A, Gummert J, Haverich A, Schmitto JD, Sossalla S. Inhibition of CaMKII attenuates progressing disruption of Ca2+ homeostasis upon LVAD implantation in human heart failure. Artif. Organs 2016; 40:719-26. 53. Hartmann N, Mason F, Braun I, Pabel S. Voigt N, Schotola H, Fischer TH, Dobrev D, Danner BC, Renner A, Gummert J, Belardinelli L, Frey N, Maier LS, Hasenfuss G, Sossalla S. The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology. J Mol Cell Cardiol. 2016; 94:95-10. 54. Volland C, Bremer S, Hellenkamp K, Hartmann N, Dybkova N, Khadjeh S, Kutschenko A, Liebetanz D, Wagner S, Unsöld B, Didié M, Toischer K, Sossalla S, Hasenfuß G, Seidler T. Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival. Sci Rep. 2016; 6:33853. 55. Bernt A, Rangrez AY, Eden M, Jungmann A, Katz S, Rohr C, Müller OJ, Katus HA, Sossalla ST, Williams T, Ritter O, Frank D, Frey N. Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy. Sci Rep. 2016. 6:35758. 56. Vettel C, Lindner M, Dewenter M, Lorenz K, Schanbacher C, Riedel M, Lämmle S, Meinecke S, Mason FE, Sossalla S, Geerts A, Hoffmann M, Wunder F, Brunner FJ, Wieland T, Mehel H, Karam S, Lechêne P, Leroy J, Vandecasteele G, Wagner M, Fischmeister R, El-Armouche A. Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction. Circ Res. 2017; 120:120-132. 57. Hartmann N, Pabel S, Herting J, Schatter F, Renner A, Gummert J, Schotola H, Danner BC, Maier LS, Frey N, Hasenfuss G, Fischer TH, Sossalla S. Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes. Heart Rhythm. 2017; 14: 412-419. 58. Rangrez AY, Pott J, Kluge A, Frauen R, Stiebeling K, Hoppe P, Sossalla S, Frey N, Frank D. Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation. Biochim Biophys Acta. 2017; 1864:634-644. 59. Borlepawar A, Rangrez AY, Bernt A, Christen L, Sossalla S, Frank D, Frey N. TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels. J Biol Chem. 2017; 292:10180-10196. 60. Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A. Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circ Heart Fail. 2017;10:e003840. 61. Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A. Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation. Basic Res Cardiol. 2017; 112:43. 62. Dierck F, Kuhn C, Rohr C, Hille S, Braune J, Sossalla S, Molt S, van der Ven PFM, Fürst DO, Frey N. The Cardiac Z-Disc Protein CEFIP Regulates Cardiomyocyte Hypertrophy By Modulating Calcineurin Signaling. J Biol Chem. 2017; 292:15180-15191. 63. Borchert T, Hübscher D, Guessoum CI, Lam TD, Ghadri JR, Schellinger IN, Tiburcy M, Liaw NY, Li Y, Haas J, Sossalla S, Huber MA, Cyganek L, Jacobshagen C, Dressel R, Raaz U, Nikolaev VO, Guan K, Thiele H, Meder B, Wollnik B, Zimmermann WH, Lüscher TF, Hasenfuss G, Templin C, Streckfuss-Bömeke K. Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy. J Am Coll Cardiol. 2017; 70:975-991. 64. Sibbing D, Aradi D, Jacobshagen C, Gross L, Trenk D, Geisler T, Orban M, Hadamitzky M, Merkely B, Kiss RG, Komócsi A, Dézsi CA, Holdt L, Felix SB, Parma R, Klopotowski M, Schwinger RHG, Rieber J, Huber K, Neumann FJ, Koltowski L, Mehilli J, Huczek Z, Massberg S; TROPICAL-ACS Investigators. Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial. Lancet. 2017; 390:1747-1757. 65. Streckfuss-Bömeke K, Tiburcy M, Fomin A, Luo X, Li W, Fischer C, Özcelik C, Perrot A, Sossalla S, Haas J, Vidal RO, Rebs S, Khadjeh S, Meder B, Bonn S, Linke WA, Zimmermann WH, Hasenfuss G, Guan K. Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2017; 113:9-21. 66. Schotola H, Sossalla ST, Renner A, Gummert J, Danner BC, Schott P, Toischer K. The contractile adaption to preload depends on the amount of afterload. ESC Heart Fail. 2017; 4:468-478. 67. Koentges C, Pepin ME, Müsse C, Pfeil K, Alvarez SVV, Hoppe N, Hoffmann MM, Odening KE, Sossalla S, Zirlik A, Hein L, Bode C, Wende AR, Bugger H. Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans. Basic Res Cardiol. 2017;113:8. 68. Mustroph J, Wagemann O, Lebek S, Tarnowski D, Ackermann J, Drzymalski M, Pabel S, Schmid C, Wagner S, Sossalla S, Maier LS, Neef S. SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure. J Mol Cell Cardiol. 2018;116:81-90 69. Bergau L, Willems R, Sprenkeler DJ, Fischer TH, Flevari P, Hasenfuß G, Katsaras D, Kirova A, Lehnart SE, Lüthje L, Röver C, Seegers J, Sossalla S, Dunnink A, Sritharan R, Tuinenburg AE, Vandenberk B, Vos MA, Wijers SC, Friede T, Zabel M. Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy. Int J Cardiol. 2018; S0167-5273; 32262-9. 70. Dybkova N, Ahmad S, Pabel S, Tirilomis P, Hartmann N, Fischer TH, Bengel P, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Ellenberger D, Wagner S, Frey N, Maier LS, Streckfuss-Boemeke K, Hasenfuss G, Sossalla S. Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart. Cardiovasc Res. 2018; Epub ahead of print Kommentar in: Cardiovasc Res. 2018 71. Mustroph J, Wagemann O, Lücht CM, Trum M, Hammer KP, Sag CM, Lebek S, Tarnowski D, Reinders J, Perbellini F, Terracciano C, Schmid C, Schopka S, Hilker M, Zausig Y, Pabel S, Sossalla ST, Schweda F, Maier LS, Wagner S. Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes. ESC Heart Fail. 2018; Epub ahead of print. 72. Fischer T, Eiringhaus J, Dybkova N, Saadatmand A, Pabel S, Weber S, Köhn M, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Maier LS, Hasenfuss G, Sossalla S. Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure. Eur J Heart Fail. 2018. Epub ahead of print 73. Pabel S, Wagner S, Bollenberg H, Bengel P, Kovács A, Schach C, Tirilomis P, Mustroph J, Renner A, Gummert J, Fischer T, Van Linthout S, Tschöpe C, Streckfuss-Bömeke K, Hasenfuss G, Maier LS, Hamdani N, Sossalla S. Empagliflozin directly improves diastolic function in human heart failure. Eur J Heart Fail. In press. Übersichtsarbeiten/Letter/Positionspapiere: 1. Sossalla S, Hasenfuss G, Maier LS. Inhibition des späten Natriumeinstroms als neuartige kardioprotektive Therapieoption. Der Kardiologe. 2008; 2:142-148. 2. Sossalla S, Maier LS. Young ambitious cardiologists and scientific research-reasons to get involved. Pol Kardiol. 2009; 67:1310-1367. 3. Sossalla S, Schmitto JD. Scientific teamwork- A particular approach. Pol Kardiol. 12/2009:67. 4. Heidrich F, Schotola H, Popov AF, Sohns C, Schuenemann J, Friedrich M, Coskun KO, von Lewinski D, Hinz J, Bauer M, Mokashi SA, Sossalla S, Schmitto JD. AMPK - Activated Protein Kinase and its Role in Energy Metabolism of the Heart. Curr Cardiol Rev. 2010; 6:337-42. 5. Toischer K; Rokita AG, Unsöld, Wuqiang Z, Sossalla S, Reuter SP, Becker A, Teucher N, Seidler T, Grebe C, Preuß L, Gupta SN, Schmidt K, Lehnart SE, Krüger M, Linke WA, Kararigas G, Regitz-Zagrosek V, Backs J, Schäfer K, Field LJ, Maier LS, Hasenfuss G: Response to Letter Regarding Article, "Differential Cardiac Remodeling in Preload Versus Afterload". Circulation. 2010; 123:e421. 6. Schmitto JD, Mokashi SA, Lee LS, Popov AF, Coskun KO, Sossalla S, Sohns C, Bolman RM 3rd, Cohn LH, Chen FY. Large animal models of chronic heart failure. J Surg Res. 2011; 166:131-37. 7. Sossalla S, Maier LS. Role of ranolazine in angina, heart failure, arrhythmias, and diabetes. Pharmacol Therapeut. 2012; 133:311-22. 8. Fischer TH, Maier LS, Sossalla S. The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis. Heart Fail Rev. 2013; 18:475-83. 9. Maier LS & Sossalla S. The late Na current as a therapeutic target: where are we? J Mol Cellular Cardiol. 2013; 61:44-50. 10. Sossalla S, Espinola-Klein C, Hampe J, Harendza S, Herold S, Hoyer BF, Maack C, Malek N, Mischak-Weissinger EM, Müller-Marbach AM, Schulze-Lohoff E, Lammert F. Promotion von Medizinern und deren Bedeutung im Rahmen der Nachwuchsförderung. Der Internist. 2014; 55; 955-970. 11. Lammert F, Müller-Marbach AM, Espinola-Klein C, Hampe J, Harendza S, Hoyer BF, Maack C, Malek N, Mischak-Weissinger EM, Schulze-Lohoff E, Herold S, Sossalla S. Innere Medizin in Europa: Mehr Chancen für junge Internisten. Der Internist. 2014; 55; 575-589. 12. Hoyer BF, Espinola-Klein C, Hampe J, Harendza S, Herold S, Maack C, Müller-Marbach AM, Schulze-Lohoff E, Sossalla S, Lammert F, Malek N. Developing internal medicine into systems medicine: opportunities and challenges. Dtsch Med Wochenschr. 2015; 140:523-527. 13. Sossalla S, Vollmann D. Die inadäquate Sinustachykardie. Dtsch Med Wochenschr 2015; 140: 603–607. 14. Schwörer H, Sossalla S, Schillinger W. Letter: proton pump inhibitor treatment and increased mortality in cirrhotic patients. Alimentary Pharmacology and Therapeutics. 2015. 41:1224. 15. Mason F, Sossalla S. The Significance of the Late Na Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine. J Cardiovasc Pharm Ther. 2016. Epub ahead of print. 16. Bengel P, Ahmad S, Sossalla S. Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy. Curr Heart Fail Rep. 2017; 14:179-186 17. Sossalla S. Ablation outperforming antiarrhythmic drugs need for more research. Cardiovasc Res. 2017;113:e4-e5. 18. Maier LS, Sossalla S, Schulze-Bahr E. SCN10A-Dependent Late INa Current: Never Too Late for Cardiac Conduction? Circ Genom Precis Med. 2018;11:e002167. 19. Sossalla S, Vollmann D. Arrhythmia-Induced Cardiomyopathy. Dtsch Arztebl Int. 2018; 115:335-341. 20. Maier LS, Sossalla S, Schulze-Bahr E. SCN10A-Dependent Late INa Current: Never Too Late for Cardiac Conduction? Circ Genom Precis Med. 2018; 11:e002167. Case Reports: 1. Sossalla S, Sohns C, Seegers J, Lüthje L, Vollmann D, Zabel M. Ranolazine maintained sinus rhythm in a patient with refractory symptomatic atrial fibrillation. Cardiovasc Ther. 2013; 31:303-306. 2. Vollmann D, Sossalla S, Schroeter MR, Zabel M. Renal artery ablation instead of pulmonary vein ablation in a hypertensive patient with symptomatic, drug-resistant, persistent atrial fibrillation. Clin Res Cardiol. 2013; 102:315-318. 3. Sossalla S, Seegers J, Lüthje L, Sohns C, Vollmann D, Zabel M. Ventricular Oversensing after ICD Lead Replacement: What Is the Mechanism? PACE. 2014; 37:1076-9. 4. Sossalla S, Frank D, Frey N. Fatal myocardial infarction due to pseudo aneurysm of the aortic annulus after TAVR. Clin Res Cardiol. 2017; 106:468-470. 5. Eiringhaus J, Hamer OW, Hollemann D, Brochhausen C, Vollmann D, Maier LS, Sossalla S.The detrimental potential of arrhythmia-induced cardiomyopathy. ESC Heart Fail. 2018 Aug 6. doi: 10.1002/ehf2.12343. [Epub ahead of print]

Kooperationsangebot für die Wirtschaft / Praxis:

• Entwicklung neuer Antiarrhythmika wie z.B. spezifischer Nav1.8 Inhibitoren

Bestehende Kooperationen: