Universität Regensburg

Charlotte Wagner

Anschrift:

Leistungsprofil:

• Regulation der Nierenfunktion
• Regulation des Renin-Angiotensin-Systems
• Zelluläre /interzelluläre Signalwege und Nierenfibrose

• Rolle von Pannexin -1 bei der Progression einer Nierenfibrose
• Rolle des Purinoceptors P2X Typ 7 (P2X7R) bei der Progression einer Nierenfibrose
• Bedeutung der interzellulären Kommunikation bei der Progression einer Nierenfibrose.

• Tiermodelle
• Immunfluoreszenz
• mRNAscope Technik

Publikationen:

• Geis L, Boudriot FF, Wagner C. Connexin mRNA distribution in adult mouse kidneys Pflugers Arch. 2021 Nov;473(11):1737-1747. doi: 10.1007/s00424-021-02608-0. Epub 2021 Aug 7. PMID: 34365513
• Schrankl J, Fuchs M, Broeker K, Daniel C, Kurtz A, Wagner C. Localization of angiotensin II type 1 receptor gene expression in rodent and human kidneys. Am J Physiol Renal Physiol. 2021 Apr 1;320(4):F644-F653. doi: 10.1152/ajprenal.00550.2020. Epub 2021 Feb 22. PMID: 33615887
• Neder TH, Schrankl J, Fuchs MAA, Broeker KAE, Wagner C. Endothelin receptors in renal interstitial cells do not contribute to the development of fibrosis during experimental kidney disease. Pflugers Arch. 2021 Oct;473(10):1667-1683. doi: 10.1007/s00424-021-02604-4. Epub 2021 Aug 6. PMID: 34355294
• Broeker KAE, Fuchs MAA, Schrankl J, Kurt B, Nolan KA, Wenger RH, Kramann R, Wagner C, Kurtz A. Different subpopulations of kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in vivo. Kidney Int. 2020 Oct;98(4):918-931. doi: 10.1016/j.kint.2020.04.040. Epub 2020 May 23. PMID: 32454122
• Schrankl J, Neubauer B, Fuchs M, Gerl K, Wagner C, Kurtz A. Apparently normal kidney development in mice with conditional disruption of ANG II-AT1 receptor genes in FoxD1-positive stroma cell precursors. Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1191-F1200. doi: 10.1152/ajprenal.00305.2018. Epub 2019 Apr 10. PMID: 30969804
• Le Gal L, Pellegrin M, Santoro T, Mazzolai L, Kurtz A, Meda P, Wagner C, Haefliger JA. Connexin37-Dependent Mechanisms Selectively Contribute to Modulate Angiotensin II -Mediated Hypertension. J Am Heart Assoc. 2019 Apr 16;8(8):e010823. doi: 10.1161/JAHA.118.010823. PMID: 30943815
• Neubauer B, Schrankl J, Steppan D, Neubauer K, Sequeira-Lopez ML, Pan L, Gomez RA, Coffman TM, Gross KW, Kurtz A, Wagner C. Angiotensin II Short-Loop Feedback: Is There a Role of Ang II for the Regulation of the Renin System In Vivo? Hypertension. 2018 Jun;71(6):1075-1082. doi: 10.1161/HYPERTENSIONAHA.117.10357. Epub 2018 Apr 16. PMID: 29661841
• Steppan D, Geis L, Pan L, Gross K, Wagner C, Kurtz A. Lack of connexin 40 decreases the calcium sensitivity of renin-secreting juxtaglomerular cells. Pflugers Arch. 2018 Jun;470(6):969-978. doi: 10.1007/s00424-018-2119-y. Epub 2018 Feb 9. PMID: 29427253
• Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B. Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol. 2017 Jul;187(7):1496-1511. doi: 10.1016/j.ajpath.2017.03.014. Epub 2017 May 17. PMID: 28527294
• Gerl M, Vöckl J, Kurt B, van Veen TA, Kurtz A, Wagner C. Inducible deletion of connexin 40 in adult mice causes hypertension and disrupts pressure control of renin secretion. Kidney Int. 2015 Mar;87(3):557-63. doi: 10.1038/ki.2014.303. Epub 2014 Sep 17. PMID: 25229336

Kooperationsangebot für die Wirtschaft / Praxis:

Bestehende Kooperationen: