Universität Bayreuth

Clemens Steegborn

Anschrift:

Leistungsprofil:

• Strukturuntersuchungen zur Signaltransduktion bei Alterungs-und Krankheitsprozessen
• Rationale Wirkstoffentwicklung von Kleinmolekül Enzym-Modulatoren
• Interaktionsstudien von Signalmolekülen

• Entwicklung von Sirtuin 2 Inhibitoren als Wirkstoffe zur Behandlung der Alzheimer-Krankheit
• Molecular mechanisms regulating the metabolic sensor soluble adenylyl cyclase and development of specific pharmacological modulators
• Strukturelle Charakterisierung von Proteinen aus Biomaterialien

• nano-Liter Pipettierroboter für die Proteinkristallisation, Kristall-Imaging & Storage System
• Röntgengenerator mit ImagePlate, 3D-Workstations
• nano-HPLC gekoppelte hoch-und niedrigauflösende Massenspektrometer, UPLC
• Microscale Thermophorese
• Isotherme-Titrations-Kalorimetrie

Publikationen:

• 1) C. Roessler, T. Nowak, M. Pannek, M. Gertz, G.T. Nguyen, M. Scharfe, I. Born, W. Sippl, C. Steegborn, M. Schutkowski (2014) Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors. Angew. Chem. Int. Ed. Engl. in press. doi: 10.1002/anie.201402679
• 2) U. Schweizer, C. Schlicker, D. Braun, J. Köhrle, C. Steegborn (2014) Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism. Proc. Natl Acad. Sci. USA 111, 10526-31.
• 3) M.H. Suhre, M. Gertz, C. Steegborn, T. Scheibel (2014) Structural and functional features of a collagen-binding matrix protein from the mussel byssus. Nat. Commun. 5:3392.
• 4) S. Kleinboelting, A. Diaz, S. Moniot, J. van den Heuvel, M. Weyand, L.R. Levin, J. Buck, C. Steegborn (2014) Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. Proc. Natl Acad. Sci. USA 111, 3727-32.
• 5) G.T.T. Nguyen, S. Schaefer, M. Gertz, M. Weyand, C. Steegborn (2013) Crystal structures of Sirt3 complexes with the resveratrol derivative 5-(2-(4-bromophenyl)vinyl)-1,3-benzenediol reveal binding sites and inhibition mechanism. Chem. Biol. 20:1375-85.
• 6) D. Rauh, F. Fischer, M. Gertz, M. Lakshminarasimhan, T. Bergbrede, F. Aladini, C. Kambach, C.F.W. Becker, J. Zerweck, M. Schutkowski, C. Steegborn (2013). An acetylome peptide microarray reveals specificities and deacetylation substrates for all human Sirtuin isoforms. Nat. Commun. 4:2327
• 7) M. Gertz, F. Fischer, G.T.T. Nguyen, M. Lakshminarasimhan, M. Schutkowski, M. Weyand, C. Steegborn (2013) Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc. Natl Acad. Sci. USA 110:E2772-81.
• 8) G. Laurent, N.J. German, A.K. Saha, V.C. de Boer, M. Davies, T.R. Koves, N. Dephoure, F. Fischer, G. Boanca, B. Vaitheesvaran, S.B. Lovitch, A.H. Sharpe, I.J. Kurland, C. Steegborn, S.P. Gygi, D.M. Muoio, N.B. Ruderman, M.C. Haigis (2013) SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol. Cell 50, 686-98.
• 9) M. Lakshminarasimhan, D. Rauh, M. Schutkowski, C. Steegborn (2013) Sirt1 activation by resveratrol is substrate sequence-selective. Aging 5, 151-4.

Kooperationsangebot für die Wirtschaft / Praxis:

• Wirkstoffentwicklung

Bestehende Kooperationen: