Universität Regensburg

Matthias Mack

Anschrift:

Leistungsprofil:

• Autoimmunerkrankungen und Inflammation
• Transplantation
• Chemokine
• Basophile Granulozyten
• Fibrose

• Arthritis, Nephritis, Encephalitis, Colitis
• Herztransplantation Maus
• CCR2, CCR5
• Immunregulation
• Nierenfibrose, Herzfibrose

• Tiermodelle
• FACS, ELISA, Zellkultur, Westernblot
• In vitro Modelle für Inflammation

Publikationen:

• 35. Renner, K, Hellerbrand, S, Hermann, F, Riedhammer, C, Talke, Y, Schiechl, G, Gomez, MR, Kutzi, S, Halbritter, D, Goebel, N, Brühl, H, Weissert, R and Mack, M. IL-3 promotes the development of experimental autoimmune encephalitis. JCI Insight 2016 Oct 6;1(16):e87157.
• 34. Schiechl, G, Hermann, FJ, Rodriguez Gomez, M, Kutzi, S, Schmidbauer, K, Talke, Y, Neumayer, S, Goebel, N, Renner, K, Bruhl, H, Karasuyama, H, Obata-Ninomiya, K, Utpatel, K, Evert, M, Hirt, SW, Geissler, EK, Fichtner-Feigl, S and Mack, M. Basophils trigger fibroblast activation in cardiac allograft fibrosis development. Am J Transplant 2016, Am J Transplant. 2016;16(9):2574-88.
• 33. Renner, K, Hermann, FJ, Schmidbauer, K, Talke, Y, Rodriguez Gomez, M, Schiechl, G, Schlossmann, J, Bruhl, H, Anders, HJ and Mack, M. IL-3 contributes to development of lupus nephritis in MRL/lpr mice. Kidney Int 2015. 88: 1088-1098.
• 31. Bruhl, H, Cihak, J, Talke, Y, Rodriguez Gomez, M, Hermann, F, Goebel, N, Renner, K, Plachy, J, Stangassinger, M, Aschermann, S, Nimmerjahn, F and Mack, M. B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis. Eur J Immunol 2015. 45: 705-715.
• 29. Rodrigues Gomez, M, Talke, Y, Hofmann, C, Ketelsen, I, Hermann, F, Reich, B, Goebel, N, Schmidbauer, K, Dunger, N, Brühl, H, Renner, K, Syed, S-N and Mack, M. Basophils control T cell Responses and limit Disease Activity in Experimental Murine Colitis. Mucosal Immunol 2014. 7: 188-199.
• 28. Reich, B, Schmidbauer, K, Rodriguez Gomez, M, Johannes Hermann, F, Gobel, N, Bruhl, H, Ketelsen, I, Talke, Y and Mack, M. Fibrocytes develop outside the kidney but contribute to renal fibrosis in a mouse model. Kidney Int 2013. 84: 78-89.
• 27. Rodriguez Gomez, M, Talke, Y, Goebel, N, Hermann, F, Reich, B and Mack, M. Basophils support the survival of plasma cells in mice. J Immunol 2010. 185: 7180-7185.
• 26. Niedermeier, M, Reich, B, Rodrigues Gomez, M, Denzel, A, Schmidbauer, K, Goebel, N, Talke, Y, Schweda, F and Mack, M. CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes. Proc Natl Acad Sci U S A 2009. 106:17892-17897.
• 24. Denzel, A, Maus, U, Rodriguez Gomez, M, Moll, C, Niedermeier, M, Winter, C, Maus, R, Hollingshead, S, Briles, DE, Kunz-Schughart, L, Talke, Y and Mack, M. Basophils enhance immunological memory responses. Nature Immunology 2008. 9:733-742.

Kooperationsangebot für die Wirtschaft / Praxis:

• Entwicklung eines blockierenden Antikörpers gegen IL-3 zur Behandlung von Autoimmunerkrankungen
• Depletion von Monozyten zur Behandlung von Autoimmunerkrankungen