Universität Regensburg

Stefan M. Brunner

Anschrift:

Leistungsprofil:

• Chirurgische Forschung
• Tranplantationschirurgie- und immunologie
• Onkologische Forschung
• Klinische Studien

Publikationen:

• Veröffentlichungen 1. Junger H, Mühlbauer M, Brennfleck FW, Schurr LA, Goetz M, Eggenhofer E, Kirchner G, Evert K, Fichtner-Feigl S, Geissler EK, Schlitt HJ, Brunner SM. Early γGT and bilirubin levels as biomarkers for regeneration and outcomes in damaged bile ducts after liver transplantation. Clin Transplant. 2022 Dec 15:e14880. doi: 10.1111/ctr.14880 Impact Factor 3.456 2. Schurr LA, Thiedemann C, Alt V, Schlitt HJ, Götz M, Riedl M, Brunner SM, Popp D. Diaphragmatic Injuries among Severely Injured Patients (ISS ≥ 16)-An Indicator of Injury Pattern and Severity of Abdominal Trauma. Medicina (Kaunas). 2022 Nov 4;58(11):1596. Impact Factor 2.430 3. Goetz M, Jurczyk M, Junger H, Schlitt HJ, Brunner SM, Brennfleck FW. Semiresorbable biologic hybrid meshes for ventral abdominal hernia repair in potentially contaminated settings: lower risk of recurrence. Updates Surg. 2022 Oct 12. doi: 10.1007/s13304-022-01378-3 Impact Factor 2.692 4. Goetz M, Jurczyk M, Grothues D, Knoppke B, Junger H, Melter M, Schlitt HJ, Brunner SM, Brennfleck FW. Biological abdominal wall expansion in pediatric liver recipients after transplantation with large-for-size organs. Pediatr Transplant. 2022 Oct 6:e14405. doi: 10.1111/petr.14405 Impact Factor 1.551 5. Pion E, Karnosky J, Boscheck S, Wagner BJ, Schmidt KM, Brunner SM, Schlitt HJ, Aung T, Hackl C, Haerteis S. 3D In Vivo Models for Translational Research on Pancreatic Cancer: The Chorioallantoic Membrane (CAM) Model. Cancers (Basel). 2022 Jul 31;14(15):3733. doi: 10.3390/cancers14153733 Impact Factor 6.575 6. Badawy A, Brunner SM, Knoppke B, Völkl M, Junger H, Loss M, Sinner B, Huf V, Grothues D, Melter M, Schlitt HJ. Predictors of portal vein complications after pediatric liver transplantation: A German center experience. Pediatr Transplant. 2022 Apr 22:e14298. doi: 10.1111/petr.14298 Impact Factor 1.502 7. Junger H, Luerken L, Kees MG, Prasser C, Scharf G, Eissnert C, Schlitt A, Brennfleck FW, Dienemann T, Graf BM, Stroszczynski C, Brunner SM, Schlitt HJ. Successful surgical-multimodal treatment for vaccine-induced complete splanchnic vein thrombosis after ChAdOx1 nCoV-19 vaccination. Br J Surg. 2022 Mar 2:znac051. doi: 10.1093/bjs/znac051 Impact Factor 6.939 8. Dienemann T, Brennfleck F, Dejaco A, Grützmann R, Binder J, Krautz C, Stöß C, Jäger C, Friess H, Schlitt HJ, Brunner SM. Collateral effects of the SARS-CoV-2 pandemic on oncologic surgery in Bavaria. BMC Surg. 2021 Dec 4;21(1):411. doi: 10.1186/s12893-021-01404-y Impact Factor 2.102 9. Dollinger M, Bäumler W, Brunner SM, Stroszczynski C, Georgieva M, Müller K, Schicho A, Müller-Wille R. Role of clinical and CT findings in the identification of adult small-bowel intussusception requiring surgical intervention. BJS Open. 2021 Sep 6;5(5):zrab076. doi: 10.1093/bjsopen/zrab076 Impact Factor 3.396 10. COVIDSurg Collaborative; GlobalSurg Collaborative. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaesthesia. 2022 Jan;77(1):28-39. doi: 10.1111/anae.15563 Impact Factor 6.995 11. COVIDSurg Collaborative; GlobalSurg Collaborative. Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. Anaesthesia. 2021 Nov;76(11):1454-1464. doi: 10.1111/anae.15560 Impact Factor 6.955 12. COVIDSurg Collaborative Co-authors. Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score. Br J Surg. 2021 Nov 11;108(11):1274-1292. doi: 10.1093/bjs/znab183 Impact Factor 5.676 13. Dobsch P, Brunner SM, Knoppke B, Schlitt HJ, Kandulski A. Intraoperative digital single-operator cholangioscopy - extra-anatomical biliary access and insights into severe sclerosing cholangitis in a pediatric patient. Endoscopy. 2021 Jun 8. doi: 10.1055/a-1494-2854 Impact Factor 7.341 14. Luerken L, Doppler M, Brunner SM, Schlitt HJ, Uller W. Stereotactic Percutaneous Electrochemotherapy as Primary Approach for Unresectable Large HCC at the Hepatic Hilum. Cardiovasc Intervent Radiol. 2021 Sep;44(9):1462-1466. doi: 10.1007/s00270-021-02841-1 Impact Factor 2.191 15. COVIDSurg Collaborative, GlobalSurg Collaborative. SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. Br J Surg. 2021 Sep 27;108(9):1056-1063. doi: 10.1093/bjs/znab101 Impact Factor 5.676 16. Brunner SM, Brennfleck FW, Junger H, Grosse J, Knoppke B, Geissler EK, Melter M, Schlitt HJ. Successful auxiliary two-staged partial resection liver transplantation (ASPIRE-LTx) for end-stage liver disease to avoid small-for-size situations. BMC Surg. 2021 Mar 26;21(1):166. doi: 10.1186/s12893-021-01167-6 Impact Factor 1.912 17. Huf VI, Grothues D, Knoppke B, Goessmann H, Wohlgemuth WA, Melter M, Brunner SM, Schlitt HJ, Uller W. Super selective percutaneous transhepatic coil embolization of intrahepatic pseudoaneurysm after pediatric liver transplantation: a case report. CVIR Endovasc. 2021 Mar 19;4(1):31. doi: 10.1186/s42155-021-00221-x Impact Factor 1.928 18. COVIDSurg Collaborative; GlobalSurg Collaborative. Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study. Anaesthesia. 2021 Jun;76(6):748-758. doi: 10.1111/anae.15458 Impact Factor 5.739 19. Brennfleck FW, Linsenmeier L, Junger HHG, Schmidt KM, Werner JM, Woehl D, Zeman F, Mutzbauer I, Hutchinson JA, Geissler EK, Schlitt HJ, Brunner SM. Negative pressure wound therapy (NPWT) on closed incisions to prevent surgical site infection in high-risk patients in hepatopancreatobiliary surgery: study protocol for a randomized controlled trial-the NP-SSI trial. Trials. 2020 Nov 9;21(1):918. doi: 10.1186/s13063-020-04831-z Impact Factor 2.000 20. Brennfleck FW, Bachmeier T, Simet W, Zeman F, Junger HHG, Schlitt HJ, Dahlke MH, Brunner SM. Surgical Site Infections and their economic significance in hepatopancreatobiliary surgery: A retrospective incidence, cost, and reimbursement analysis in a German centre of the highest level of care. Int Wound J. 2021 Feb;18(1):17-23. doi: 10.1111/iwj.13511. Epub 2020 Oct 2. Impact Factor 2.825 21. Platz Batista da Silva N, Engeßer M, Hackl C, Brunner S, Hornung M, Schlitt HJ, Evert K, Stroszczynski C, Jung EM. Intraoperative Characterization of Pancreatic Tumors Using Contrast-Enhanced Ultrasound and Shear Wave Elastography for Optimization of Surgical Strategies. J Ultrasound Med. 2021 Aug;40(8):1613-1625. doi: 10.1002/jum.15545 Impact Factor 1.759 22. Balam S, Kesselring R, Elke E, Blaimer S, Evert K, Evert M, Schlitt HJ, Geissler EK, van Blijswijk J, Lee S, Reis E Sousa C*, Brunner SM*, Fichtner-Feigl S*. Cross-presentation of dead-cell-associated antigens by DNGR-1+ dendritic cells contributes to chronic allograft rejection in mice. Eur J Immunol. 2020 Dec;50(12):2041-2054. doi: 10.1002/eji.201948501 *contributed equally Impact Factor 4.404 23. Junger H, Knoppke B, Weigand K, Evert K, Brennfleck FW, Melter M, Schlitt HJ, Brunner SM. Living donor liver transplantation from hepatitis C-infected donor to hepatitis C-infected recipient. Hepatology. 2020 Sep;72(3):1148-1151. doi: 10.1002/hep.31185 Impact Factor 16.581 24. Li J, Moustafa M, Linecker M, Lurje G, Capobianco I, Baumgart J, Ratti F, Rauchfuss F, Balci D, Fernandes E, Montalti R, Robles-Campos R, Bjornsson B, Topp SA, Fronek J, Liu C, Wahba R, Bruns C, Brunner SM, Schlitt HJ, Heumann A, Stüben BO, Izbicki JR, Bednarsch J, Gringeri E, Fasolo E, Rolinger J, Kristek J, Hernandez-Alejandro R, Schnitzbauer A, Nuessler N, Schön MR, Voskanyan S, Petrou AS, Hahn O, Soejima Y, Vicente E, Castro-Benitez C, Adam R, Tomassini F, Troisi RI, Kantas A, Oldhafer KJ, Ardiles V, de Santibanes E, Malago M, Clavien PA, Vivarelli M, Settmacher U, Aldrighetti L, Neumann U, Petrowsky H, Cillo U, Lang H, Nadalin S. ALPPS for Locally Advanced Intrahepatic Cholangiocarcinoma: Did Aggressive Surgery Lead to the Oncological Benefit? An International Multi-center Study. Ann Surg Oncol. 2020 May;27(5):1372-1384. doi: 10.1245/s10434-019-08192-z. Impact Factor 3.780 25. Brennfleck FW, Junger HHG, Przemyszlaw S, Mauerer C, Brunner SM, Schlitt HJ, Hornung M. Management of Open Abdominal Wounds With Intestinal Fistula Formation Using a Combination of Negative Pressure Wound Therapy With Instillation and Dwell Time and New Generation Fistula Devices: A Case Report. Wounds. 2020 Dec;32(12):E62-E66. Impact Factor 1.326 26. Schnitzbauer AA, Eberhard J, Bartsch F, Brunner SM, Ceyhan GO, Walter D, Fries H, Hannes S, Hecker A, Li J, Oldhafer K, Rahbari N, Rauchfuss F, Schlitt HJ, Settmacher U, Stavrou G, Weitz J, Lang H, Bechstein WO, Rückert F. The MEGNA Score and Preoperative Anemia are Major Prognostic Factors After Resection in the German Intrahepatic Cholangiocarcinoma Cohort. Ann Surg Oncol. 2020 Apr;27(4):1147-1155. doi: 10.1245/s10434-019-07968-7 Impact Factor 3.681 27. Verloh N, Einspieler I, Utpatel K, Menhart K, Brunner S, Hofheinz F, van den Hoff J, Wiggermann P, Evert M, Stroszczynski C, Hellwig D, Grosse J. In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by 18F-FDG PET/CT. EJNMMI Res. 2018 Nov 9;8(1):98. doi: 10.1186/s13550-018-0452-y. Impact Factor 2.110 28. da Silva NPB, Hornung M, Beyer LP, Hackl C, Brunner S, Schlitt HJ, Wiggermann P, Jung EM. Intraoperative Shear Wave Elastography vs. Contrast-Enhanced Ultrasound for the Characterization and Differentiation of Focal Liver Lesions to Optimize Liver Tumor Surgery. Ultraschall Med. 2019 Apr;40(2):205-211. doi: 10.1055/a-0649-1000. Impact Factor 4.389 29. Haimerl M., Probst U, Poelsterl S, Fellner C, Nickel D, Weigand K, Brunner SM, Zeman F, Stroszczynski C, Wiggermann P. Evaluation of two-point Dixon water-fat separation for Gd-EOB-DTPA-enhanced MRI-based estimation of liver function. Sci Rep. 2018 Sep 14;8(1):13863. doi: 10.1038/s41598-018-32207-6. Impact Factor 4.609 30. Hackl C, Brunner SM, Schmidt KM, Schlitt HJ. Surgical innovations in treatment of metastatic colorectal cancer : Complexity of metastatic surgery as example for personalized medicine. Chirurg. 2018 Mar;89(3):191-196. doi: 10.1007/s00104-017-0583-0. Impact Factor 0.646 31. Brunner SM, Itzel T, Rubner C, Kesselring R, Griesshammer E, Evert M, Teufel A, Schlitt HJ, Fichtner-Feigl S. Tumor-infiltrating B cells producing antitumor active immunoglobulins in resected HCC prolong patient survival. Oncotarget. 2017 Aug 9;8(41):71002-71011. doi: 10.18632/oncotarget.20238. eCollection 2017 Sep 19. Impact Factor 5.168 32. Junger HH, Schlitt HJ, Geissler EK, Fichtner-Feigl S, Brunner SM. Bile duct regeneration and immune response by passenger lymphocytes signals biliary recovery versus complications after liver transplantation. Liver Transpl. 2017 Nov;23(11):1422-1432. doi: 10.1002/lt.24836. Impact Factor 3.910 33. Seebauer CT, Brunner S, Glockzin G, Piso P, Ruemmele P, Schlitt HJ, Geissler EK, Fichtner-Feigl S, Kesselring R. Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells. Oncoimmunology. 2016 Oct 14;5(12):e1242543. doi: 10.1080/2162402X.2016.1242543. eCollection 2016. Impact Factor 7.719 34. Brunner SM, Hahn U, Jeiter T, Kesselring R, Rubner C, Ruemmele P, Sziklavari Z, Hofmann HS, Schlitt HJ, Fichtner-Feigl S. Immune Architecture of Colorectal Lung Metastases and Implications for Patient Survival. Eur Surg Res. 2016;57(3-4):186-196. Epub 2016 Jul 22. Impact Factor 1.382 35. Kesselring R, Glaesner J, Hiergeist A, Naschberger E, Neumann H, Brunner SM, Wege AK, Seebauer C, Köhl G, Merkl S, Croner RS, Hackl C, Stürzl M, Neurath MF, Gessner A, Schlitt HJ, Geissler EK, Fichtner-Feigl S. IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3. Cancer Cell. 2016 May 9;29(5):684-96. doi: 10.1016/j.ccell.2016.03.014. Epub 2016 Apr 14. Impact Factor 27.407 36. Brunner SM, Weber F, Werner JM, Agha A, Farkas SA, Schlitt HJ, Hornung M. Neuroendocrine tumors of the pancreas: a retrospective single-center analysis using the ENETS TNM-classification and immunohistochemical markers for risk stratification. BMC Surg. 2015 Apr 25;15:49. doi: 10.1186/s12893-015-0033-1. Impact Factor 1.240 37. Martin M, Kesselring RK, Balam S, Brunner SM, Schiechl G, Mouris VF, Wege AK, Rümmele P, Schlitt HJ, Geissler EK, Fichtner-Feigl S. RORγt+ hematopoietic cells are necessary for tumor cell proliferation during colitis-associated tumorigenesis in mice. Eur J Immunol. 2015 Jun;45(6):1667-79. doi: 10.1002/eji.201444915. Impact Factor 4.518 38. Scheller T, Hellerbrand C, Moser C, Schmidt K, Kroemer A, Brunner SM, Schlitt HJ, Geissler EK, Lang SA. mTOR inhibition improves fibroblast growth factor receptor targeting in hepatocellular carcinoma. Br J Cancer. 2015 Mar 3;112(5):841-50. doi: 10.1038/bjc.2014.638. Epub 2015 Feb 17. Impact Factor 4.817 39. Brunner SM, Christoph Rubner, Rebecca Kesselring, Maria Martin, Petra Ruemmele, Teufel Andreas, Hans J. Schlitt, Stefan Fichtner-Feigl. Tumor-infiltrating, interleukin-33-producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival. Hepatology. 2015 Jun;61(6):1957-67. doi: 10.1002/hep.27728. Impact Factor 11.190 40. Brunner SM, Rebecca Kesselring, Christoph Rubner, Maria Martin, Tonia Jeiter, Thomas Boerner, Petra Ruemmele, Hans J. Schlitt, Stefan Fichtner-Feigl. Prognosis according to histochemical analysis of liver metastases removed at liver resection. Br J Surg. 2014 Dec;101(13):1681-91. doi: 10.1002/bjs.9627. Epub 2014 Oct 21. Impact Factor 5.210 41. Kesselring R, Thiel A, Pries R, Fichtner-Feigl S, Brunner S, Seidel P, Bruchhage KL, Wollenberg B. The complement receptors CD46, CD55 and CD59 are regulated by the tumour microenvironment of head and neck cancer to facilitate escape of complement attack. Eur J Cancer. 2014 Aug;50(12):2152-61. doi: 10.1016/j.ejca.2014.05.005. Impact Factor 5.061 42. Fichtner-Feigl S, Kesselring R, Martin M, Obermeier F, Ruemmele P, Kitani A, Brunner SM, Haimerl M, Geissler EK, Strober W, Schlitt HJ. IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3β. J Immunol. 2014 Apr 15;192(8):3969-80. doi: 10.4049/jimmunol.1301072. Epub 2014 Mar 14. Impact Factor 5.520 43. Brunner SM, Schiechl G, Kesselring R, Martin M, Balam S, Schlitt HJ, Geissler EK, Fichtner-Feigl S. IL-13 signaling via IL-13Ralpha2 triggers TGF-beta1-dependent allograft fibrosis. Transplant Res. 2013 Oct 22;2(1):16. 44. Schleder S, Brunner S, Huber E, Schleder M, Schreyer AG. Das Wunderlich-Syndrom - eine seltene Differenzialdiagnose des akuten Abdomens. Rofo. 2014 Feb;186(2):173-4. doi: 10.1055/s-0033-1335980. Impact Factor 2.758 45. Schiechl G, Brunner SM, Kesselring R, Martin M, Ruemmele P, Mack M, Hirt SW, Schlitt HJ, Geissler EK, Fichtner-Feigl S. Inhibition of innate co-receptor TREM-1 signaling reduces CD4(+) T cell activation and prolongs cardiac allograft survival. Am J Transplant. 2013 May;13(5):1168-80. doi: 10.1111/ajt.12186. Epub 2013 Mar 6. Impact Factor 6.192 46. Brunner SM, Junger H, Ruemmele P, Schnitzbauer AA, Doenecke A, Kirchner GI, Farkas SA, Loss M, Scherer MN, Schlitt HJ, Fichtner-Feigl S. Bile duct damage after cold storage of deceased donor livers predicts biliary complications after liver transplantation. J Hepatol. 2013 Jun;58(6):1133-9. doi: 10.1016/j.jhep.2012.12.022. Epub 2013 Jan 12. Impact Factor 10.401 47. Brunner SM, Schiechl G, Falk W, Schlitt HJ, Geissler EK, Fichtner-Feigl S. Interleukin-33 prolongs allograft survival during chronic cardiac rejection. Transpl Int. 2011 Oct;24(10):1027-39. doi: 10.1111/j.1432-2277.2011.01306.x. Epub 2011 Jul 28. Impact Factor 3.160 48. Comman A, Brunner SM, Gaetzschmann P, Kipf B, Baierl W, Behrend M. Incarcerated femoral Littre's hernia-transperitoneal preperitoneal hernia repair (TAPP) and laparoscopic resection of the necrotic diverticulum. Surg Laparosc Endosc Percutan Tech. 2008 Aug;18(4):409-13. doi: 10.1097/SLE.0b013e31816f7742. Impact Factor 0.940 49. Brunner SM, Comman A, Gaetzschmann P, Kipf B, Behrend M. Laparoscopic removal of a perforating intrauterine device mimicking chronic appendicitis. J Laparoendosc Adv Surg Tech A. 2008 Aug;18(4):609-10. doi: 10.1089/lap.2007.0155. Impact Factor 1.190 Gesamt Impact Factor 231.947

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